The final word on proton pump inhibitors and osteoporosis?

نویسنده

  • Lauren B Gerson
چکیده

Nuzhat A. Ahmad, Philadelphia, PA Joseph Anderson, White River Junction, VT Darren M. Brenner, Chicago, IL Andrew T. Chan, Boston, MA Francis K. L. Chan, Hong Kong, China Lin Chang, Los Angeles, CA Tsutomu Chiba, Kyoto, Japan Massimo Colombo, Milan, Italy B. Joseph Elmunzer, Ann Arbor, MI Timothy B. Gardner, Lebanon, NH Lauren B. Gerson, Stanford, CA W. Ray Kim, Rochester, MN Paul Y. Kwo, Indianapolis, IN Josep M. Llovet, New York, NY Edward V. Loftus, Rochester, MN Julian Panes, Barcelona, Spain Laurent Peyrin-Biroulet, Vandoeuvre-lès-Nancy, France Sameer Saini, Ann Arbor, MI Shiv K. Sarin, New Delhi, India Shamita B. Shah, Stanford, CA Pratima Sharma, Ann Arbor, MI Amit Singal, Dallas, TX Jan Tack, Leuven, Belgium Akbar Waljee, Ann Arbor, MI Kenneth K. Wang, Rochester, MN Alastair J. M. Watson, Norwich, United Alex Ford, Leeds, United Kingdom Joel H. Rubenstein, Ann Arbor, MI Kingdom

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Pantoprazole, a proton pump inhibitor, increases orthodontic tooth movement in rats

Objective(s):Pantoprazole, is a proton pump inhibitor (PPI) prescribed for the treatment of upper gastrointestinal disorders, which in high doses has been suggested to decrease calcium absorption leading to hypocalcaemia and therefore osteoporosis. The aim of this study was to assess whether pantoprazol, could alter the rate of orthodontic tooth movement (OTM) in rats. Materials and Methods: A ...

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Use of proton pump inhibitors and risk of osteoporosis-related fractures.

BACKGROUND The use of proton pump inhibitors has been associated with an increased risk of hip fracture. We sought to further explore the relation between duration of exposure to proton pump inhibitors and osteoporosis-related fractures. METHODS We used administrative claims data to identify patients with a fracture of the hip, vertebra or wrist between April 1996 and March 2004. Cases were e...

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Menopause and decrease of estrogenic hormones lead to osteoporosis. Treatment of osteoporosis by estrogenic hormones like estrogen in women has resulted in secondary complications such as cancers of breast and genital system. Activity of osteoclasts for removing bone is necessary to secretion of H+ ions on bone matrix. Today, using proton pump inhibitors to inhibit the activity of osteoclasts i...

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Proton-Pump Inhibitors: Reducing their Unnecessary Use

While proton-pump inhibitors (PPIs) have beneficial therapeutic and prophylactic indications for many patients, increasing evidence suggests that these medications are not without risk; inpatient use of PPIs has been shown to increase the risk of hospital-acquired pneumonia by up to 30% [2]. Community-acquired pneumonia is also more common in patients who have started PPI therapy within the pas...

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Chronic Asthma and Gastro-Esophageal Reflux Disease: The Treatment Plans

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عنوان ژورنال:
  • Gastroenterology

دوره 144 3  شماره 

صفحات  -

تاریخ انتشار 2013